The total solution of in-situ monitoring of ODS and HFCs is composed of sampling pipelines and filter, an optional water condenser, an air sampling module, an ODS5-PRO instrument (including GC-MS), standardgas, auxiliary gases (helium and nitrogen), and a computer used as a data server. Ambient air is drawn from the top of sampling tower to ODS5-PRO by an air pump in the air sampling module continuously, and send into the system by another sampling pump during sampling stage. Raw data is collected by the internal computer of ODS5-Pro and then uploaded to data server though WIFI or mobile networks. The ODSData software installed on the data server can process received data automatically to obtain concentration-time profile for each compound.